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Abstract The morphology and motion of auroras have been widely studied due to their indications on magnetospheric processes. Here, we report a new kind of “auroral curls,” which have wavelengths in the mesoscale (∼100 km) and propagate azimuthally. Utilizing data from the Chinese Antarctic Zhongshan Station (the all‐sky imager and the high‐frequency radar), the Active Magnetosphere and Planetary Electrodynamics Response Experiment and the Defense Meteorological Satellite Program, we analyze an event occurred on 23 April 2019. We find these curls are fine structures in the poleward boundary of multiple arcs. Corresponding field‐aligned currents manifest as a series of longitudinally arranged pairs, while ionospheric flow velocities nearby oscillate with periods in the Pc 5 band. Observational evidence suggests these curls are connected with ultra‐low frequency (ULF) waves, which opens the possibility of using auroras to globally image ULF waves. 

Abstract Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for neurodegenerative diseases, leading us to examine whether pathways of disease progression are shared across neurodegenerative conditions. Here we use single-nucleus RNA sequencing to profile lesions from 11 postmortem human retinas with age-related macular degeneration and 6 control retinas with no history of retinal disease. We create a machine-learning pipeline based on recent advances in data geometry and topology and identify activated glial populations enriched in the early phase of disease. Examining single-cell data from Alzheimer’s disease and progressive multiple sclerosis with our pipeline, we find a similar glial activation profile enriched in the early phase of these neurodegenerative diseases. In late-stage age-related macular degeneration, we identify a microglia-to-astrocyte signaling axis mediated by interleukin-1 β which drives angiogenesis characteristic of disease pathogenesis. We validated this mechanism using in vitro and in vivo assays in mouse, identifying a possible new therapeutic target for AMD and possibly other neurodegenerative conditions. Thus, due to shared glial states, the retina provides a potential system for investigating therapeutic approaches in neurodegenerative diseases.